HGNC announcements
- Alliance of Genomic Resources cross references now in REST
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Previous announcements
- New website to be released 13th November 2018 (May 30, 2018)
- New species data available in HCOP (May 30, 2018)
- genenames.org is now HTTPS compliant (Sep 27, 2017)
- New species’ data in VGNC (Aug 21, 2017)
- RNAcentral IDs are now in genenames.org (Mar 10, 2017)
- HGNC gene names are now in RNAcentral (Jan 11, 2017)
- Announcing the Vertebrate Gene Nomenclature Committee (Oct 12, 2016)
- New results towards gene therapy from a dog model of Duchenne muscular dystrophy (Oct 30, 2015)
- Beta release of the new gene families & minor changes (Jan 28, 2015)
- New HCOP Orthology Predictions Search Tool released! (Jul 21, 2014)
- Multiple homologs per species (Jul 17, 2014)
- New “REFERENCES” section with the Symbol reports (Mar 13, 2014)
- Multiple OMIM IDs (Feb 7, 2014)
- New features (Jan 8, 2014)
- New “Specialist Database” link for solute carrier (SLC) genes (May 22, 2013)
- snx27 protein and down syndrome (Mar 27, 2013)
- TBX18 gene therapy for the heart (Dec 19, 2012)
- syngap1 mutation affects brain development (Nov 27, 2012)
- PARK2 is associated with age-related back pain (Sep 25, 2012)
- Genes influence face shape (Sep 14, 2012)
- DCN is linked to prostate cancer (Aug 6, 2012)
- TNFRSF1A variant explains failed multiple sclerosis drug (Jul 9, 2012)
- GNL3 is associated with osteoarthritis (Jul 6, 2012)
- KATNAL1 has a role in spermiogenesis (May 25, 2012)
- SRGAP2 paralog has been linked to human brain development (May 9, 2012)
- ATM methylation status may help predict breast cancer cases (May 1, 2012)
- IFITM3 is linked to influenza virus susceptibility (Mar 26, 2012)
- Rare Disease Day (Feb 28, 2012)
- Circadian control of TLR9 activity affects immune response (Feb 20, 2012)
- Further success with RPE65 gene therapy (Feb 9, 2012)
- A variant of the CYP27B1 gene is linked to multiple sclerosis (Dec 9, 2011)
Alliance of Genomic Resources cross references now in REST
Feb 26, 2020
We have now added cross references to the human gene pages for the Alliance of Genome Resources via our REST API. See our REST help page for more information. See our REST help page for more information.
How to use the cross reference to link to AGR?
The Alliance of Genomic Resources uses our HGNC ID as a unique identifier for the Human gene pages found within the resource. When “fetching” a gene symbol report using our REST service you may now see a field within the XML or JSON labelled “agr” with a value being an HGNC ID (see our REST help page). Use this ID within the URL template below:
https://www.alliancegenome.org/gene/<HGNC ID>
Future additions
In a couple of days (Friday 28th Feb 2020) we shall be adding the Alliance of Genomic Resources links to our gene symbol reports and adding the cross reference ID to our Custom downloads tool and the download files found on our Statistic and downloads pages. Soon after we will also add the AGR cross reference IDs to our BioMart server.
Previous announcements
New website to be released 13th November 2018 (May 30, 2018)
At 10am GMT on 13th November we will release our new website (currently https://beta.genenames.org), which may cause minor disruptions to our service during that day. The old look site will be available at https://old.genenames.org for the next 2 months. Thanks to all that gave us feedback.
New species data available in HCOP (May 30, 2018)
We are pleased to announce that HCOP now contains orthology data for two new species, cat (Felis catus) and fission yeast (Schizosaccharomyces pombe). The addition of S. pombe includes gene nomenclature and orthology data from PomBase.
genenames.org is now HTTPS compliant (Sep 27, 2017)
Our sites www.genenames.org and vertebrate.genenames.org are now HTTPS compliant at the request of many of our users and will redirect all HTTP requests to HTTPS. Our REST (rest.genenames.org) and BioMart (biomart.genenames.org) services are also HTTPS compliant however; we have decided that these services should also continue to serve via HTTP….
New species’ data in VGNC (Aug 21, 2017)
We are pleased to announce that the VGNC is now assigning unique symbols, names and numerical identifiers to chimpanzee, horse, cow and dog genes, based on consensus orthology to human genes. Please contact us at vgnc@genenames.org with feedback on the nomenclature or the functionality of the VGNC website.
RNAcentral IDs are now in genenames.org (Mar 10, 2017)
We have recently added RNAcentral IDs to the ‘nucleotide sequences’ section of the appropriate non-coding RNA Symbol Reports. For example, see the URS000075AC83 ID on the ZEB1-AS1 Symbol Report. Clicking on the adjacent RNAcentral link takes you through to the RNAcentral sequence record. The mapped RNAcentral IDs are fully searchable…
HGNC gene names are now in RNAcentral (Jan 11, 2017)
We are delighted to announce that RNAcentral are using HGNC data as a source of human non-coding RNAs. As a result, HGNC gene names are being displayed on RNAcentral sequence records. For more information on how RNAcentral have mapped in our gene names, read their blog.
Announcing the Vertebrate Gene Nomenclature Committee (Oct 12, 2016)
The Vertebrate Gene Nomenclature Committee (VGNC) is an extension of the HGNC. VGNC is responsible for assigning standardized names to genes in vertebrate species that currently lack a nomenclature committee. The 6 existing vertebrate nomenclature committees and VGNC coordinate to ensure genes are named in line with their human homologs….
New results towards gene therapy from a dog model of Duchenne muscular dystrophy (Oct 30, 2015)
There has been some promising research into gene therapy for Duchenne Muscular Dystrophy, caused by mutation of DMD, coding for the protein dystrophin. This is a particularly large gene (2.5mb, containing 79 exons) which causes a problem in its delivery using a gene therapy vector.
Beta release of the new gene families & minor changes (Jan 28, 2015)
New gene families beta released, minor REST API change and search result improvements.
New HCOP Orthology Predictions Search Tool released! (Jul 21, 2014)
A new and improved version of our HCOP tool has been released. This updated version of HCOP includes ortholog data from eggNOG, Ensembl Compara, HGNC, HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, TreeFam and ZFIN. The new HCOP also features a revamped, more user-friendly interface and ortholog data for three…
Multiple homologs per species (Jul 17, 2014)
We have recently updated the HOMOLOGS section of our symbol reports to show multiple mouse and rat homologs for each human gene, where applicable. This also means that there will be multiple MGI or RGD IDs within the download files, which are comma space (ie ‘, ‘) separated within the…
New “REFERENCES” section with the Symbol reports (Mar 13, 2014)
We have improved the REFERENCES section within the Symbol Report pages to display the title, authors and citation of the publications as well as providing links out to Europe PMC and Pubmed. Next to the links you will find a ‘+’ icon and clicking on this icon will additionally reveal…
Multiple OMIM IDs (Feb 7, 2014)
Since some of our symbols can link to more than one OMIM entry, you may find that some symbol reports now have multiple OMIM cross reference (i.e IGH) when in the past we displayed one. This change has also affected the “Complete HGNC Dataset” download file (available on our Statistics…
New features (Jan 8, 2014)
Introducing a new solr search, a REST web service a root symbol word cloud and many other changes.
New “Specialist Database” link for solute carrier (SLC) genes (May 22, 2013)
We have added a new “Specialist Database” link for all genes within the solute carrier (SLC) gene family. The link will take the format “BioParadigms: <Symbol>” and will link to the BioParadigms SLC tables which provide up-to-date information on the SLC families and their members, as well as relevant links…
snx27 protein and down syndrome (Mar 27, 2013)
Researchers have shown that restoring the protein encoded by Snx27 in the mouse model for Down syndrome improves cognitive function and behaviour. It is suggested that the extra copy of chromosome 21 in people with Down Syndrome triggers the loss of the SNX27 protein and could be the cause of…
TBX18 gene therapy for the heart (Dec 19, 2012)
Researchers have transfected guinea pig hearts with a copy of the human TBX18 gene to create a new biological pacemaker that controls heartbeat. The TBX18 gene is active in human embryonic hearts at the stage where pacemaker cells are formed. The study has led to hopes that the technique may…
syngap1 mutation affects brain development (Nov 27, 2012)
Studies in mice have cast light on why mutations in the SYNGAP1 gene cause intellectual disability in humans. Mice carrying mutated copies of Syngap1 showed above average levels of synaptic communication between neurons. It is thought that this results in disruption of brain development. For more on this story, see…
PARK2 is associated with age-related back pain (Sep 25, 2012)
A recent study has found that specific variants of the PARK2 gene are associated with lumbar disc degeneration. The disc degeneration causes nearby vertebrae to develop osteophytes, resulting in lower back pain. For more on this story see www.bbc.co.uk/news/health-19674045
Genes influence face shape (Sep 14, 2012)
A study has recently associated five genes with different face shapes: PRDM16, PAX3, TP63, C5orf50, and COL17A1, see www.bbc.co.uk/news/science-environment-19566022.
DCN is linked to prostate cancer (Aug 6, 2012)
A recent study found that prostate tumour cells have lower levels of DCN (decorin) than normal prostate cells. Scientists hope that measuring levels of decorin may provide a diagnostic test for prostate cancer in the future. For more on this story, see www.bbc.co.uk/news/uk-scotland-edinburgh-east-fife-19121402.
TNFRSF1A variant explains failed multiple sclerosis drug (Jul 9, 2012)
A study has recently shown why anti-TNF drugs, which help treat autoimmune conditions such as rheumatoid arthritis, exacerbate multiple sclerosis. Researchers found that a variant of the TNFRSF1A gene previously associated with increased risk of developing multiple sclerosis encodes a shorter form of the TNFRSF1A protein. This shortened protein blocks…
GNL3 is associated with osteoarthritis (Jul 6, 2012)
A recent study has found that a polymorphism in the GNL3 gene is associated with osteoarthritis. This work is an important step in understanding the risk factors involved in this common disease. Further research is needed to characterise the function of the gene and the role of the variant in…
KATNAL1 has a role in spermiogenesis (May 25, 2012)
A study in mice has shown that the KATNAL1 ortholog is needed for the final stages of sperm development. The finding has lead to hopes that the gene could be a target for future reversible male contraceptives. For more on this story, see www.bbc.co.uk/news/health-18190352.
SRGAP2 paralog has been linked to human brain development (May 9, 2012)
A human-specific paralog of SRGAP2 may have influenced human brain development. SRGAP2C is a duplication of SRGAP2 that encodes a shorter protein compared to SRGAP2; the SRGAP2C protein can bind to SRGAP and inhibit its function. This results in an increase of neuron migration and the production of more dendritic…
ATM methylation status may help predict breast cancer cases (May 1, 2012)
A recent study has found that women with high methylation levels of the ATM gene in white blood cells are far more likely to develop breast cancer than women with low methylation levels at the locus. Researchers hope that the finding could lead to screening tests in the future to…
IFITM3 is linked to influenza virus susceptibility (Mar 26, 2012)
The IFITM3 gene has been shown to be important for host defences against viruses. Researchers found that Ifitm3 knockout mice show an increase in serious symptoms when challenged with flu virus. Sequencing of the IFITM3 gene from patients in hospital due to flu infection showed that a statistically significant number…
Rare Disease Day (Feb 28, 2012)
This year 29th February is the fifth international Rare Disease Day. The theme of the event this year is “solidarity” with a focus on research and clinical collaboration, and support for patients and families. For more information about the day, please visit http://www.rarediseaseday.org
Circadian control of TLR9 activity affects immune response (Feb 20, 2012)
Researchers have found that the activity of TLR9, which has a role in pathogen recognition, varies throughout the day, following a set pattern controlled by the body clock. Mice immunised at the time of day where TLR9 activity is at its peak showed a greater immune response to the vaccine….
Further success with RPE65 gene therapy (Feb 9, 2012)
Three patients with Leber’s Congenital Amaurosis (LCA) that received gene therapy to introduce functional copies of the RPE65 gene in a second eye have reported inprovements in their vision. The patients had received gene therapy in one eye back in 2008 and follow-up treatment to the second eye has proved…
A variant of the CYP27B1 gene is linked to multiple sclerosis (Dec 9, 2011)
A recent study found that individuals carrying rare variant copies of the CYP27B1 gene have a much greater risk of developing multiple sclerosis. This provides support for theories that vitamin D levels may be linked to incidence of multiple sclerosis; the CYP27B1 product is involved in processing vitamin D into…